Е. Б. Любов ФГУ «Московский НИИ психиатрии» Минздравсоцразвития России линии при поддерживающей терапии больных шизофренией по сравнению с оланзапином (зипрекса) и рисперидоном (рисполептом). Ключевые слова: шизофрения, фармакоэкономический прогноз, сероквель пролонг. PHARMACOECONOMIC PROGNOSIS OF LONGTERM MAINTENANCE SCHIZOPHRENIA THERAPY WITH QUETIAPINE EXTENDED RELEASE, RISPERIDONE (RISPOLEPT), OLANZAPINE (ZYPREXA), AND TYPICAL ANTIPSYCHOTICS E. B. Lyubov The Markov model of pharmacoeconomic prognosis (costutility analysis) for a fiveyear maintenance treatment with Seroquel Prolong and a number of atypical and conventional neuroleptics has connected the clinically grounded population approach to maintenance therapy of schizophrenics and patients in specific subgroups with economic conditions of psychiatric care in the Russian Federation. This model is close to the clinical practice and it takes into account standard factors that influence the outcome of medication such as compliance, relapses, switching over to another medication, risks of adverse effects, post-schizophrenic depression and polypharmacotherapy and their influence on patients’ quality of life and the costs of treatment. In the antirelapse treatment, the safety of medication and its tolerability significantly influence the costs of medication with atypical antipsychotics or conventional neuroleptics. Treatment with conventional neuroleptics is 27% to 35% cheaper than treatment with atypical antipsychotics but it is inferior in terms of ‘usefulness’ and the duration of remission (in days outside hospital). Thus the results of the pharmacoeconomic analysis provide an evidencebased data for considering Seroquel Prolong as a firstchoice medication in the maintenance treatment of schizophrenic patients, in comparison with Olanzapine (Zyprexa) and Risperidone (Rispolept). Key words: schizophrenia, pharmacoeconomic prognosis, Seroquel Prolong, Quetiapine Extended Release. Любов Евгений Борисович – доктор медицинских наук, профессор, руководитель отделения суицидологии ФГУ «Московский НИИ психиатрии» Минздравсоцразвития России; e-mail: lyubov.evgeny@mail.ru |
Информационные ресурсы > Журналы > Журнал "Социальная и клиническая психиатрия" > "Социальная и клиническая психиатрия" том XXI, выпуск 2, 2011 год >